The cell is a highly crowded nanoscale environment where biological molecules meet, interact and function. For the correct control of gene regulation, the interactions between various proteins, DNA and RNA molecules must be carefully coordinated. Understanding what controls these interactions allows us to define the mechanisms behind various diseases and to then pursue new therapeutics. For example, most cancers, many neurodegenerative diseases and a number of other hereditary conditions are caused by misregulation of gene expression. In my lab we use a combination of biological chemistry, molecular biology and structural biology methods to build a three-dimensional picture of these key molecular interactions, and we collaborate closely with labs with complementary expertise in cell biology and genetics.
If that sounds interesting, and you'd like to join us, have a look at this page for details.
How do the proteins and nucleic acids in the human cell nucleus interact to control gene regulation?
These amazing molecules could be the reagents and therapeutics of the future...
We are unpicking the interactions between molecules that are affected in ALS/MND.
If you've got an idea for a project why not come and discuss it?